PK/PD Modeling
Effective dose selection and therapeutic monitoring hinge on understanding pharmacokinetics (PK) and pharmacodynamics (PD). This is especially critical for narrow therapeutic index drugs, biologics, and oncology products.
What we do
Compartmental Modeling
Develop models representing drug distribution across body compartments to predict concentration-time profiles.
Non-Compartmental Analysis (NCA)
Perform NCA to estimate pharmacokinetic parameters without assuming specific compartmental models.
Dose-Exposure-Response Simulation
Simulate relationships between dosing regimens, drug exposure, and therapeutic responses.
AI-Enhanced Curve Fitting
Employ artificial intelligence to improve the accuracy and efficiency of model fitting processes.
Business Value
Reduces Phase I/II uncertainty, supports rational dose selection, bridges gaps in pediatric/geriatric labeling, and underpins labeling negotiations.